Prince Harry, Jennifer Lopez Make Voices Heard at Vax Live

President Joe Biden spoke about the COVID-19 vaccination being safe, Prince Harry urged for the vaccine distribution everywhere and Jennifer Lopez embraced her fully-vaccinated mother on stage during one of the largest concert gatherings in Southern California since the pandemic rocked the world more than a year ago.

Celebrities and political leaders gathered Sunday night to talk about the importance of vaccine equity at Global Citizen's "Vax Live: The Concert to Reunite the World" at SoFi Stadium in Inglewood, California. The taped fundraising event will air May 8 on ABC, ABC News Live, CBS, YouTube and iHeartMedia broadcast radio stations.

The concert included performances by Lopez, Eddie Vedder, Foo Fighters, J Balvin and H.E.R.

Ben Affleck, Chrissy Teigen, Jimmy Kimmel, Sean Penn and David Letterman appeared as special guest speakers.

Everyone in the audience was fully vaccinated. Media and production staff needed to show a negative COVID test before entering the stadium.

"The vaccines are safe. I promise you. They work," said Biden, who was accompanied in a video message with first lady Jill Biden. Both appeared as part of the "We Can Do This" initiative to increase confidence in COVID-19 vaccines.

"We're working with leaders around the world to share more vaccines and boost production to make sure every country has the vaccines they need," the president continued. "If we get this done, we won't have to miss another moment."

The event was part of a growing chorus seeking wider, more equitable distribution of COVID-19 vaccines.

Global Citizen said $53.8 million in philanthropic and corporate commitments helped procure nearly 10.3 million doses, exceeding the goal for the Vax Live campaign.

Prince Harry said providing vaccines across the globe is imperative, particularly those in the poorest countries. He said that he is standing solidarity with India, who is experiencing a "devastating" second wave of the virus.

"The vaccine must be distributed to everyone everywhere," the Duke of Sussex said. He along with his wife Meghan are leading an effort to raise money for the vaccine-sharing program COVAX, which hopes to produce $19 billion to pay for the vaccines for medical workers.

"We cannot rest or truly recover until there is fair distribution to every corner of the world," he said. "The virus does not respect borders and access to the vaccine cannot be determined by geography."

The event also highlighted first responders and health care workers efforts during the pandemic. Selena Gomez, the show's host, called essential and frontline workers "reliable" and "brave."

"Many of us had to stay home, but you all didn't have a choice," the singer said. "You set an example for all of us, both in how you stayed on the job and that we need to get vaccinated as soon as possible."

Each musical performance made things seem almost like normal with attendees standing at their seats side-by-side while others danced with their masks on. Some hugged each other with enthusiasm.

H.E.R. performed on a small stage outside the stadium with a group of people playing their guitars.

Before Lopez's performance, she told the audience that she was unable to spend Christmas with her mother. The singer went on to invite her fully-vaccinated mom on stage, then the two sang their rendition of Neil Diamond's "Sweet Caroline."

"When I was thinking about what song to sing tonight, I remembered the song she used to sing to me as a baby," said Lopez, who later performed her 2016 hit single "Ain't Your Mama."

Eddie Vedder said the concert was the first "taste of the life we've all been missing" for more than a year.

"This is a feeling we have not had in some time," he said. "There's a microphone, a crowd. It feels good."

Foo Fighters rocked on with AC/DC frontman Brian Johnson during a performance of the rock anthem "Back In Black."

"We ain't out the woods yet. But let me tell you, I'm a firm believer and idea that music should be shared with people," Foo Fighters frontman Dave Grohl said. "Let's work as hard as we can to make sure we can do this every night."

Hugh Evans, founder and CEO of Global Citizen, said he wants to keep the momentum going.

"What were trying to highlight is the obvious that we should be fighting for equity," he said. "It's something that shouldn't require any arithmetic. It is absolutely bleeding obvious."